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Exarchates of Ravenna and Africa set up immediately after 584. Immediately after substantial territorial losses in the seventh century, the remaining provinces had been superseded from the concept program in c. 640–660, Though in Asia Slight and parts of Greece they survived underneath the themes till the early 9th century.

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MCLA-129 is designed to have two complementary mechanisms of motion: blocking development and survival pathways to halt tumor expansion and recruitment and improvement of immune effector cells to eradicate the tumor.

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